Supplementary Table 2.
50% Inhibitory Concentration Values of Ribavirin Against Identified Hepatitis C Virus Genotype 3a Polymorphisms Compared With the Wild-Type S52 Replicon
| S52 replicon | RBV IC50 (85% CI), μM | Fold-change in RBV IC50 | Luciferase levels, % of Wt, mean ± SEM |
|---|---|---|---|
| Wt | 0.70 (0.47–1.05) | 1.00 | 100.00 ± 10.33 |
| K100R | 23.61 (9.96–55.95) | 32.85 | 72.45 ± 13.18 |
| A150V | 28.03 (17.14–45.83) | 40.04 | 98.17 ± 11.59 |
| G188D | 15.19 (4.94–46.67) | 21.70 | 74.02 ± 17.11 |
| K206E | 7.40 (4.66–11.75) | 10.57 | 59.35 ± 21.05 |
| T213N | 6.12 (3.58–10.54) | 8.74 | 108.20 ± 18.19 |
| N244I | 1.49 (0.78–2.86) | 2.13 | 55.95 ± 13.01 |
| K100R+G188D | 7.27 (5.15–10.25) | 10.35 | 40.96 ± 14.51 |
| A150V+K206E | 48.69 (20.81–113.9) | 69.55 | 120.4 ± 17.75 |
NOTE. The calculated IC50 values with 95% CIs and the fold-change compared to the Wt replicon from Supplementary Figures 3 and 4 were replicons were treated with RBV, are summarized. Relative luciferase levels compared to the Wt replicon construct for each polymorphism were also included.