REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Caspase 3	Abcam	Cat# ab2302; RRID: AB_302962
Histone H2A.X (phospho Ser139)	Millipore	Cat# 05-636; RRID:AB_309864
53BP1	Novusbio	Cat# NB100-304; RRID:AB_10003037
GFP/YFP	Thermo Fisher Scientific	Cat# A10262; RRID:AB_2534023
Cytokeratin 4	Abcam	Cat# ab9004; RRID:AB_306932
alpha-Tubulin	Cell signaling	Cat# 2125; RRID:AB_2619646
Ki67	Abcam	Cat# ab15580; RRID:AB_443209
Histone H3 (phospho Ser10)	Abcam	Cat# ab14955; RRID:AB_443110
Nrf2 (phospho Ser40)	Abcam	Cat# ab76026; RRID:AB_1524049
Chk1	Santa Cruz	Cat# sc-8408; RRID:AB_627257
Chk1 (phosphor Ser345)	Cell Signaling	Cat# 2348; RRID:AB_331212
Chk2	Cell Signaling	Cat# 2662; RRID:AB_2080793
Chk2 (phospho Thr68)	Cell Signaling	Cat# 2661; RRID:AB_331479
p53	Vector Laboratories	Cat# VP-P956; RRID: AB_2335917
p53 (phospho Ser15)	Cell signaling	Cat# 9284; RRID: AB_331464
p38 MAPK	Cell signaling	Cat# 9212; RRID:AB_330713
p38 MAPK (phosphor Thr180/Tyr182)	Cell signaling	Cat# 9215; RRID:AB_331762
Alexa Fluor 647 Wheat Germ Agglutinin	Invitrogen	Cat# W32466
Alexa Fluor 647 anti-human/mouse CD49f	BioLegend	Cat# 313610; RRID:AB_493637
Alexa Fluor 488 Donkey Anti-Chicken	Jackson ImmunoResearch	Cat# 703-545-155; RRID:AB_2340375
Alexa Fluor 555 Donkey Anti-Mouse	Thermo Fisher Scientific	Cat# A-31570; RRID:AB_2536180
Alexa Fluor 555 Donkey Anti-Rabitt	Thermo Fisher Scientific	Cat# A-31572; RRID:AB_162543
Alexa Fluor 647 Donkey Anti-Rabitt	Thermo Fisher Scientific	Cat# A-31573; RRID:AB_2536183
Alexa Fluor 488 Donkey Anti-Mouse	Thermo Fisher Scientific	Cat# A-21202; RRID:AB_141607
Bacterial and Virus Strains
Adeno-CMV-iCre	Vector Laboratories	Cat# 1045
Chemicals, Peptides, and Recombinant Proteins
β-Napthoflavone	MP Biomedicals	Cat# 156738
Tamoxifen	Sigma Aldrich	Cat# N3633
Fish Skin gelatin	Sigma Aldrich	Cat# G7765
Bovine Serum Albumin	Merk Millipore	Cat# 126575
Donkey serum	Sigma Aldrich	Cat# D9633
N-Ethylmaleimide	Sigma Aldrich	Cat# 04259-5G
Sodium Hidroxide	VWR	Cat# 191373M
N-Acetyl L-Cysteine	LKT Labs	Cat# A0918
Hydrogen Peroxide 30%	Merk Millipore	Cat# 107298
DMEM	Thermo Fisher Scientific	Cat# 11971025
DMEM/F-12	Thermo Fisher Scientific	Cat# 31330
HBSS	GIBCO	Cat#14175-053
Insulin	Sigma Aldrich	Cat# I5500
Adenine	Sigma Aldrich	Cat# A3159
Hydrocortisone	Calbiochem	Cat# 386698
Cholera toxin	Sigma-Aldrich	Cat# C8052
Epidermal growth factor	PeproTech	Cat# 100-15
Apo-Transferrine	Sigma-Aldrich	Cat# T2036
Fetal calf serum	PAA Laboratories	Cat# A15-041
Penicillin-Streptomycin	Sigma Aldrich	Cat# P0781
Amphotericin B	Sigma Aldrich	Cat# A2942
Protease and Phosphatase inhibitor	Thermo Fisher Scientific	Cat# 78415
40, 6-diamidino-2-phenylindole (DAPI)	Sigma Aldrich	Cat# D9542
Polybrene	Sigma Aldrich	Cat# H9268
Trypsin/EDTA	Sigma Aldrich	Cat# T4174
RIPA buffer	Thermo Fisher Scientific	Cat# 89900
Pierce BCA Protein Assay Kit	Thermo Fisher Scientific	Cat# 23227
Critical Commercial Assays
Click-iT EdU imaging	Life technologies	Cat# C10086
RNeasy Mini kit	QIAGEN	Cat# 74106
Lipofectamine 2000	Thermo Fisher	Cat# 11668-019
QuickSTART Bradford Dye reagents	BioRAD	Cat# 500-0202
Maxi Prep Endotoxin free kit	QIAGEN	Cat# 12362
Wes Simple	ProteinSimple	Cat# P/N 031-108
QIAamp DNA Micro Kit	QIAGEN	Cat# 56304
Deposited Data
RNaseq data: p53wt/wt	This paper	Wt_Ctrl_1A; ENA: ERS1432686
RNaseq data: p53wt/wt	This paper	Wt_Ctrl_1B; ENA: ERS1432689
RNaseq data: p53wt/wt	This paper	Wt_Ctrl_1C; ENA: ERS1432688
RNaseq data: p53wt/wt	This paper	Wt_Ctrl_24A; ENA: ERS1432703
RNaseq data: p53wt/wt	This paper	Wt_Ctrl_24B; ENA: ERS1432704
RNaseq data: p53wt/wt	This paper	Wt_Ctrl_24C; ENA: ERS1432705
RNaseq data: p53wt/wt	This paper	Wt_50mGy_1A; ENA: ERS1432693
RNaseq data: p53wt/wt	This paper	Wt_50mGy_1B; ENA: ERS1432694
RNaseq data: p53wt/wt	This paper	Wt_50mGy_1C; ENA: ERS1432690
RNaseq data: p53wt/wt	This paper	Wt_50mGy_24A; ENA: ERS1432691
RNaseq data: p53wt/wt	This paper	Wt_50mGy_24B; ENA: ERS1432692
RNaseq data: p53wt/wt	This paper	Wt_50mGy_24C; ENA: ERS1432695
RNaseq data: p53∗/wt	This paper	p53_mut_Ctrl_1A; ENA: ERS1432636
RNaseq data: p53∗/wt	This paper	p53_mut_Ctrl_1B; ENA: ERS1432637
RNaseq data: p53∗/wt	This paper	p53_mut_Ctrl_1C; ENA: ERS1432634
RNaseq data: p53∗/wt	This paper	p53_mut_Ctrl_24A; ENA: ERS1432638
RNaseq data: p53∗/wt	This paper	p53_mut_Ctrl_24B; ENA: ERS1432635
RNaseq data: p53∗/wt	This paper	p53_mut_Ctrl_24C; ENA: ERS1432639
RNaseq data: p53∗/wt	This paper	p53_mut_50mGy_1A; ENA: ERS1432640
RNaseq data: p53∗/wt	This paper	p53_mut_50mGy_1B; ENA: ERS1432641
RNaseq data: p53∗/wt	This paper	p53_mut_50mGy_1C; ENA: ERS1432642
RNaseq data: p53∗/wt	This paper	p53_mut_50mGy_24A; ENA: ERS1432643
RNaseq data: p53∗/wt	This paper	p53_mut_50mGy_24B; ENA: ERS1432647
RNaseq data: p53∗/wt	This paper	p53_mut_50mGy_24C; ENA: ERS1432644
RNaseq data: Nrf2−/−	This paper	NRF2KO_Ctrl_1A; ENA: ERS1432706
RNaseq data: Nrf2−/−	This paper	NRF2KO_Ctrl_1B; ENA: ERS1432707
RNaseq data: Nrf2−/−	This paper	NRF2KO_Ctrl_1C; ENA: ERS1432708
RNaseq data: Nrf2−/−	This paper	NRF2KO_Ctrl_24A; ENA: ERS1432709
RNaseq data: Nrf2−/−	This paper	NRF2KO_Ctrl_24B; ENA: ERS1432710
RNaseq data: Nrf2−/−	This paper	NRF2KO_Ctrl_24C; ENA: ERS1432711
RNaseq data: Nrf2−/−	This paper	NRF2KO_50mGy_1A; ENA: ERS1432712
RNaseq data: Nrf2−/−	This paper	NRF2KO_50mGy_1B; ENA: ERS1432713
RNaseq data: Nrf2−/−	This paper	NRF2KO_50mGy_1C; ENA: ERS1432714
RNaseq data: Nrf2−/−	This paper	NRF2KO_50mGy_24A; ENA: ERS1432715
RNaseq data: Nrf2−/−	This paper	NRF2KO_50mGy_24B; ENA: ERS1432716
RNaseq data: Nrf2−/−	This paper	NRF2KO_50mGy_24C; ENA: ERS1432717
Experimental Models: Cell Lines
Human derived amphotrophic phoenix cell	ATCC	ATCC CRL-3213
Experimental Models: Organisms/Strains
Mouse: C57BL/6J	The Jackson Laboratory	JAX: 000664
Mouse: Nfe2l2−/−	Chan et al., 1996	JAX: 017009
Mouse: AhcreERTTrp53flR245W/wt	Murai et al., 2018	N/A
Mouse: AhcreERTRosa26flYFP/wt	Clayton et al., 2007	N/A
Recombinant DNA
pLPCX/mito-roGFP2-Grx1	Addgene	#64977
Software and Algorithms
LAS X	Leica	N/A
Volocity 6 and 6.3	Perkin Elmer	N/A
Imaris	Bitplane	N/A
GraphPad	Prism 6	N/A
STAR 2.5.3a	Dobin et al., 2013	N/A
HTSeq framework version 0.6.1p1	Anders et al., 2015	N/A
R package: DESeq2	Love et al., 2014	https://bioconductor.org/packages/release/bioc/html/DESeq2.html
R package: pheatmap		https://cran.r-project.org/web/packages/pheatmap/index.html
R package: RColorBrewer		https://cran.r-project.org/web/packages/RColorBrewer/index.html
R package: clusterProfiler	Yu et al., 2012	https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html
R package: org.Mm.eg.db		https://bioconductor.org/packages/release/data/annotation/html/org.Mm.eg.db.html
MATLAB R2016b	MathWorks	N/A
Jupyter & Spyder 3.1 (Python 3)	Python Software Foundation	N/A
Other
Leica TCS SP8	Leica	N/A
RS225 X-Ray irradiator	Xstrahl	RS225
Caesium source irradiator	Gamma-Service medical GmbH	GSR D1
UNIDOS E universal dosimeter	PTW	N/A
UV-irradiator CL-508M	Uvitec	N/A