FIG 1.

Overall transcriptomic changes of C. albicans growing under filament-inducing conditions in response to treatment with compound 9029936. (A) Principal-component analysis (PCA) plot showing the level of correlation and reproducibility among control untreated samples (purple) and samples treated with 5 μM compound 9029936 (orange). (B) Hierarchical-clustering heat map of gene expression data. The color scale indicates the degree of correlation (red, high correlation; blue, low correlation), while the height of the dendrogram branches represents the variability in gene expression between samples. (C) Volcano plot showing the significantly upregulated (red) and downregulated (blue) genes in samples treated with compound 9029936. A cutoff absolute value of log fold change >1 (2-fold change) was used. Adjusted P value < 0.05.