FIG 3.

Network visualization for predicted protein-protein interactions and expression levels of genes involved in the core filamentation response network. The STRING database is a curated knowledge database of known and predicted protein-protein associations. The genes whose protein products are known or predicted to have direct protein-protein interaction are highlighted. The eight genes identified as forming part of the C. albicans core filamentation response network are represented by ovals. All other interacting genes are represented by circles. The relative expression levels of genes in C. albicans cells treated with 5 μM compound 9029936 versus untreated control cultures are represented by a gradient of colors from green (downregulation) to red (upregulation) indicating log2 fold changes. The input genes are drawn as filled nodes when their protein structures are known or predicted, while unfilled nodes are used for the additional genes with unknown protein structures.