Figure 1.

Study Design and Visualizing Dynamical Complexity

(A) Conceptual overview of the study design. iPSCs from seven neurotypical controls and eight ASD cases were differentiated into neurons. Neurons were characterized through RNA sequencing and MEA recordings to identify disease signatures that integrate across both levels of analysis.

(B) Dynamical complexity may vary even when standard spiking variables are constant. For these pedagogical examples, the firing rate is constant at 20 spiking events in the interval. Nevertheless, differences in the organization of the spiking events may result in large differences in complexity, as measured by dynamical analysis. These differences may distinguish groups of interest, such as ASD, and correlate to gene expression changes related to neuronal dysfunction.

See also Figure S1.