Figure 3.

Gene Expression Signatures of MED and ASD

(A) MED is associated with differential expression in 1,423 genes before multiple comparison correction and 53 genes after correction, as depicted in the heatmaps. Hierarchical clustering of the samples based on gene expression separates low- and high-complexity samples, as indicated by the MED color bar.

(B) Examination of ASD genes in a combined MED and ASD interaction model identifies 761 differentially expressed genes before correction and 7 differentially expressed genes after multiple comparison correction.

(C) The log₂ fold changes of the 53 differentially expressed genes after multiple comparison correction for MED are shown. The red bars correspond to genes that are negatively correlated to MED, and the blue bars correspond to genes that are positively correlated to MED. Underlined genes are also implicated in ASD risk or brain function in previous studies. Most differentially expressed genes are negatively correlated to MED, and positively correlated genes have less variability in their log fold changes.

See also Figure S4.