Table 1.
Characteristics of Subjects from which iPSC Lines Were Generated
| iPSC Lines (N = 15) |
||
|---|---|---|
| Control | ASD | |
| Samples | 7 | 8 |
| Brain volume (cm3) | 1,237.2 ± 86.6 | 1,372.9 ± 87.8 |
| Age (years) | 25.0 ± 27.7 | 13.3 ± 5.6 |
| IQ | 118.6 ± 8.6 | 67.9 ± 14.9 |
| ADOS | – | 16.75 ± 2.8 |
| Vineland ABC | 99 ± 6.2 | 57.13 ± 15.1 |
Age, IQ, ADOS, and Vineland ABC scores were recorded at the time of biopsy. Brain volume was computed via magnetic resonance imaging during early childhood. All samples were derived from males. ASD cases met the diagnostic criteria as defined by ADOS total score cutoffs or guidelines from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Where relevant, quantities are shown as averages ± one standard deviation. IQ, Wechsler Intelligence Quotient; ADOS, Autism Diagnostic Observation Schedule; Vineland ABC, Vineland Adaptive Behavioral Composite, second edition.