Table 3. Associations Between Estimated PCSK9 Expression and Sepsis-Related Adverse Outcomesa.
| Phenotype | Unadjusted | Adjusted for Age and Sex | Adjusted for Age, Sex, and Comorbidities | Adjusted for Age, Sex, Comorbidities, and 6 PCs | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Sepsis | 1.01 (0.95-1.06) | .83 | 1.01 (0.96-1.06) | .76 | 1.01 (0.95-1.06) | .86 | 1.01 (0.95-1.06) | .85 |
| Cardiovascular failure | 0.97 (0.89-1.06) | .47 | 0.97 (0.89-1.06) | .51 | 0.96 (0.88-1.05) | .41 | 0.96 (0.88-1.05) | .41 |
| In-hospital death | 1.01 (0.88-1.15) | .94 | 1.00 (0.87-1.15) | .96 | 0.99 (0.87-1.14) | .94 | 1.00 (0.87-1.15) | .99 |
Abbreviations: OR, odds ratio; PCs, principal components.
a
Includes 6033 patients with estimated PCSK9 expression.