Table 1.
Patient baseline and graft characteristics |
CS group | DS group | P-Value |
---|---|---|---|
(n=398) | (n=184) | ||
Age, years | 62.1 | 60.2 | 0.038 |
≤60yr, % | 40.5 | 49.5 | 0.042 |
>60yr, % | 59.5 | 50.5 | 0.042 |
Female, % | 22.9 | 18.5 | 0.230 |
BMI, kg/m2 | 25.3 | 26.0 | 0.007 |
Current smoking, % | 50.8 | 53.3 | 0.570 |
Diabetes mellitus, % | 37.9 | 34.8 | 0.460 |
Hypertension, % | 72.4 | 60.9 | 0.005 |
Dyslipidemia, % | 68.8 | 58.5 | 0.014 |
Acute coronary syndrome, % | 72.1 | 66.3 | 0.160 |
Left main disease, % | 38.4 | 39.1 | 0.870 |
Triple vessel disease, % | 86.7 | 85.3 | 0.660 |
Previous PCI, % | 16.8 | 8.2 | 0.002 |
Previous MI, % | 36.7 | 29.9 | 0.110 |
Stroke or TIA, % | 11.6 | 9.2 | 0.400 |
LVEF, % | 60.3 | 59.8 | 0.540 |
LDL-C, mg/dL | 96.67 | 93.97 | 0.410 |
TC, mmol/L | 4.35 | 4.19 | 0.090 |
Creatinine, mg/dL | 0.94 | 0.94 | 0.850 |
GFR, mL/min/1.73m2 † | 82.27 | 84.58 | 0.120 |
ALT, U/L | 29.17 | 36.51 | 0.004 |
AST, U/L | 22.08 | 23.63 | 0.170 |
Medication | |||
Aspirin, % | 64.1 | 78.8 | <0.001 |
Beta-blocker, % | 88.7 | 87.0 | 0.550 |
ACEI or ARB, % | 48.0 | 21.2 | <0.001 |
Distal anastomoses (mean distal) | 1275 (3.2) | 595 (3.2) | 0.683 |
Total graft | 1215 | 561 | 0.952 |
SVG | 831 | 378 | 0.614 |
Arterial graft | 384 | 183 | 0.130 |
Sequential bypass anastomoses | 60 | 34 | 0.312 |
IPW = inverse probability weighting; CS = perioperative continuation of statin therapy; DS = discontinuous statin therapy; IHD = ischemic heart disease; PCI = percutaneous coronary intervention; MI = myocardial infarction; TIA = transient ischemic attack; LVEF = left ventricular ejection fraction; LDL-C = low-density lipoprotein cholesterol; TC = total cholesterol; GFR = glomerular filtration rate; ALT = alanine transaminase; AST = aspartate aminotransferase; ACEI = angiotensin-converting-enzyme inhibitor; ARB = angiotensin receptor blocker; SVG = saphenous vein graft.
†The glomerular filtration rate (GFR) was estimated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.