Table 5.
Secondary outcomes: effect on liver function and clinical outcomes at discharge.
| Secondary outcomes | Before IPW Adjustment | After IPW Adjustment | ||||
|---|---|---|---|---|---|---|
| CS group (n=398) |
DS group (n=184) |
P-Value | CS group | DS group | P-Value | |
| LDL-C, mg/dL | 65.35 | 76.57 | 0.038 | 65.02 | 78.56 | <0.001 |
| TC, mmol/L | 3.33 | 3.56 | <0.001 | 3.32 | 3.63 | <0.001 |
| Creatinine, mg/dL | 1.04 | 1.05 | NS | 1.04 | 1.06 | NS |
| GFR, mL/min/1.73m2 † | 75.53 | 77.46 | NS | 76.28 | 76.13 | NS |
| ALT, U/L | 48.51 | 36.56 | 0.001 | 49.67 | 34.52 | <0.001 |
| AST, U/L | 33.20 | 27.97 | 0.017 | 33.54 | 28.10 | <0.001 |
| Abnormal ALT, % (n) ‡ | 8.5 (34) | 3.8 (7) | 0.038 | 8.9 | 3.1 | <0.001 |
| Abnormal AST, % (n) ‡ | 1.3 (5) | 1.1 (2) | NS | 1.2 | 1.0 | NS |
| Intraoperative blood loss, mL | 432.46 | 521.23 | 0.001 | 438.53 | 480.47 | 0.010 |
LDL-C = low-density lipoprotein cholesterol; TC = total cholesterol; GFR = glomerular filtration rate; ALT = alanine transaminase; AST = aspartate aminotransferase.
†The glomerular filtration rate (GFR) was estimated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
‡Abnormal ALT (or AST) was defined as ALT (or AST) >3×upper limit of normal (ULN).