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. 2019 Mar 11;2019:7169275. doi: 10.1155/2019/7169275

Table 2.

A comparison of coronary reactivity measures in the original and contemporary WISE cohorts.

1997-2001 2009-2011 p
Endothelial-Independent Coronary Reactivity (CFR-Ado) n=162 n=222
 Mean CFR-Ado 2.6 ± 0.8 2.7 ± 0.6 0.35
 Median (IQR) 2.5 (2.1, 3.0) 2.6 (2.2, 2.9) 0.26
 % with CFR < 2.5 48 40 0.12
 % with CFR <2.32 36 31 0.27

Endothelial-Dependent Reactivity (Δ Diam to ACH) n=107 n=162
 Mean Δ Diam 1.6 ± 12.8 0.2 ± 10.0 0.34
 Median (IQR) 2.6 (-6.4, +10.0) -0.6 (-6.4, +6.5) 0.14
 % with Δ Diam ≤ 0% (abnormal) 44 54 0.10

Endothelial-Independent Reactivity (Δ Diam to NTG) n=113 n=170
 Mean Δ Diam 9.8 ± 13.5 9.7 ± 13.0 0.94
 Median (IQR) 8.3 (2.8, 17.1) 7.6 (1.3, 18.8) 0.87
 % with Δ Diam ≤ 20% (abnormal) 83 78 0.28

p-values by t-test, Kruskal-Wallis test, and Chi Square, where appropriate.

CFR-Ado = coronary flow reserve in response to adenosine; IQR=inter-quartile range; ACH = acetylcholine; NTG = nitroglycerin.