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Western blots showing pp70S6K, pERK, and Beta-actin expression in a patient treated with sirolimus alone left panel (A) and a patient treated with sirolimus plus metformin group in the right panel (B). Reduced level of pp70S6K can be seen in both left (A) and right (B) panel.
Abbreviations: P, phorbol 12-myristate 13-acetate (PMA); I, ionomycin; C, cycle; D, day
