Table 3.

Reported cases showing a positive association between irinotecan and hypocalcemia

Case	Country	Tumor	Stage	Age	Drug treatment	Serum electrolyte abnormalities	Onset time
2003 [43]	United states	Solid tumors	NA	4–21	Cisplatin, irinotecan, amifostine	Hypocalcemia	Within 24 h after 1st treatment
2005 [44, 45]	United states	Colorectal cancer	TxNxM1	34	Cetuximab, irinotecan	Hypocalcemia, hypomagnesemia	8 weeks after 1st treatment
2009 [46]	United states	Colorectal cancer	T3N2M0	77	Cap, irinotecan, bevacizumab	Hypocalcemia, hypophosphatemia, hypokalemia, hypouricemia	5 days after the 11th treatment
2010 [47]	Japan	Colorectal cancer	TxNxM1	61	Cetuximab, irinotecan	Hypocalcemia, hypomagnesemia	NA
2012 [48]	Turkey	Breast cancer	T2N0M0	57	Irinotecan, trastuzumab	Hypokalemia, hypocalcemia, hypomagnesemia	6th week of treatment