Table 2.
Association between lifetime sleep experience and Aβ positivity (or global Aβ deposition)
| Sleep quality | Sleep duration | |||||||
|---|---|---|---|---|---|---|---|---|
| Logistic regression | Linear regression | Logistic regression | Linear regression | |||||
| aOR (95% CI)a | p | Betab | p | aOR (95% CI) | p | Beta | p | |
| Young adulthood | 1.864 (0.434–8.016) | 0.403 | 0.058 | 0.401 | 1.373 (0.913–2.063) | 0.128 | 0.099 | 0.148 |
| Midlife | 4.636 (1.448–14.844) | 0.010 | 0.174 | 0.012 | 1.170 (0.804–1.703) | 0.412 | 0.056 | 0.419 |
| Current | 4.194 (1.156–15.218) | 0.029 | 0.134 | 0.091 | 0.905 (0.665–1.233) | 0.528 | − 0.028 | 0.685 |
Both logistic and linear regression analyses were adjusted for age, gender, education, APOE4 status, vascular risk score, use of sleep pill, and Hamilton Depression Rating Score. Global Aβ deposition was natural log-transformed to achieve normal distribution
Aβ beta-amyloid, aOR adjusted odds ratio, CI confidence interval, APOE4 apolipoprotein E ε4
aGood sleep quality was taken as a reference, so aOR represents the likelihood of being Aβ positive for bad sleep quality compared with good one
bPositive beta value means that worse sleep quality is associated with increased Aβ deposition