Table 5.

Multiple linear regression analyses with neurodegeneration biomarkers as dependent variables

	Sleep quality		Sleep duration
	Betaa	p	Betaa	p
Dependent variable: AD-CM
Young adulthood	0.011	0.880	0.135	0.054
Midlife	− 0.058	0.418	0.173	0.015
Current	− 0.013	0.871	< 0.001	0.995
Dependent variable: AD-CT
Young adulthood	− 0.002	0.970	0.008	0.894
Midlife	− 0.017	0.779	− 0.001	0.987
Current	− 0.117	0.088	− 0.033	0.586

Adjusted for age, gender, education, apolipoprotein E ε4 status, vascular risk score, use of sleep pill, Hamilton Depression Rating Score. AD-CT were natural log-transformed to achieve normal distribution

AD-CM Alzheimer’s disease signature region cerebral glucose metabolism, AD-CT Alzheimer’s disease signature region cortical thickness

^aPositive beta value means that better sleep quality or decreased duration of sleep is associated with decreased glucose metabolism and/or cortical thickness, respectively