Table 3.
Foundation one histology distribution
| Disease | n | All CDKN2A | Copy # | Rearrangements | SNV: somatic | SNV: germline | SNV: unknown | SNV: all | Multiple alterations |
|---|---|---|---|---|---|---|---|---|---|
| All soft tissue sarcoma | 7733 | 16.7 | 14.0 | 0.4 | 1.1 | 0.2 | 0.7 | 2.0 | 0.3 |
| Malignant peripheral nerve sheath tumor (MPNST) | 262 | 60.7 | 48.1 | 5.3 | 5.0 | 0.4 | 1.5 | 6.9 | 0.4 |
| Myxofibrosarcoma | 140 | 29.3 | 23.6 | 1.4 | 2.1 | 0.7 | 0.7 | 3.6 | 0.7 |
| Undifferentiated pleomorphic sarcoma (UPS) | 372 | 29 | 21.5 | 0.3 | 5.1 | 0.0 | 1.3 | 6.5 | 0.8 |
| Soft tissue sarcoma (NOS) | 1476 | 28.9 | 25.4 | 0.4 | 1.3 | 0.3 | 1.1 | 2.6 | 0.5 |
| Fibrosarcoma | 99 | 26.3 | 22.2 | 0.0 | 2.0 | 0.0 | 1.0 | 3.0 | 1.0 |
| Clear cell sarcoma | 72 | 23.6 | 18.1 | 0.0 | 0.0 | 1.4 | 2.8 | 4.2 | 1.4 |
| Epithelioid sarcoma | 72 | 20.8 | 18.1 | 0.0 | 2.8 | 0.0 | 0.0 | 2.8 | 0.0 |
| Perivascular epithelioid cell tumor (PEComa) | 58 | 20.7 | 15.5 | 0.0 | 1.7 | 1.7 | 1.7 | 5.2 | 0.0 |
| Angiosarcoma | 292 | 20.2 | 16.4 | 0.3 | 1.7 | 0.3 | 1.0 | 3.1 | 0.3 |
| Endometrial stromal sarcoma | 200 | 15 | 12.5 | 0.0 | 0.5 | 0.0 | 2.0 | 2.5 | 0.0 |
| Rhabdomyosarcoma (Embryonal) | 96 | 14.6 | 10.4 | 2.1 | 1.0 | 0.0 | 1.0 | 2.1 | 0.0 |
| Rhabdomyosarcoma (NOS) | 199 | 14.1 | 12.1 | 0.0 | 2.0 | 0.0 | 0.0 | 2.0 | 0.0 |
| Hemangioendothelioma | 68 | 10.3 | 7.4 | 0.0 | 2.9 | 0.0 | 0.0 | 2.9 | 0.0 |
| Uterus leiomyosarcoma | 678 | 10.2 | 9.3 | 0.3 | 0.1 | 0.1 | 0.1 | 0.4 | 0.1 |
| Inflammatory myofibroblastic tumor | 62 | 9.7 | 8.1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 1.6 |
| Uterus sarcoma (NOS) | 129 | 9.3 | 8.5 | 0.8 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Unknown primary leiomyosarcoma | 206 | 8.7 | 7.8 | 0.0 | 0.0 | 0.0 | 1.0 | 1.0 | 0.0 |
| Rhabdomyosarcoma (Alveolar) | 101 | 6.9 | 5.0 | 0.0 | 0.0 | 1.0 | 1.0 | 2.0 | 0.0 |
| Leiomyosarcoma | 924 | 6.4 | 5.2 | 0.0 | 0.4 | 0.2 | 0.3 | 1.0 | 0.2 |
| Solitary fibrous tumor | 149 | 6 | 6.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Breast angiosarcoma | 70 | 5.7 | 5.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Synovial sarcoma | 321 | 5 | 4.0 | 0.0 | 0.0 | 0.0 | 0.6 | 0.6 | 0.3 |
| Liposarcoma | 805 | 5 | 4.5 | 0.1 | 0.1 | 0.1 | 0.1 | 0.4 | 0.0 |
| Desmoplastic small round cell tumor | 113 | 4.4 | 4.4 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Alveolar soft part sarcoma (ASPS) | 72 | 4.2 | 2.8 | 0.0 | 1.4 | 0.0 | 0.0 | 1.4 | 0.0 |