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. 2019 Sep 12;20:424. doi: 10.1186/s12891-019-2815-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Histological investigation of rabbit knee joints after three weekly injections of the HA products. Values represent the mean ± SE (n = 6; except for the saline group, n = 3). a The average synovial thickening score was increased in the Avian-CL-HA group and was significantly higher than those of the saline, Avian-HA, and Bio-HA groups. b The inflammation score was increased in the Avian-CL-HA group and was significantly higher than for the other groups. ***P < 0.001, *P < 0.05 vs. saline; †††P < 0.001, ††P < 0.01 vs. Avian-HA; ¶¶¶P < 0.001, ¶P < 0.05 vs. Bio-HA