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. 2019 Sep 12;14:9. doi: 10.1186/s13064-019-0133-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Comparison of netrin1 axon guidance models. a In the chemotaxis model, netrin1 acts as a long-range guidance signal. Commissural axons grow towards a diffusible source of netrin1 protein (green) emanating from the floor plate (FP). b In the haptotaxis model, netrin1 acts as a short-range guidance cue. Neural progenitor cells (NPCs) in the ventricular zone (VZ) express netrin1 transcript (red). Netrin1 protein (green) is trafficked to the pial surface along the radial processes of the NPCs to form a growth substrate. Commissural axons extend along this netrin1 substrate, themselves accumulating netrin1 as they grow around the VZ towards the FP. Figure adapted from [13]