Table 4.
BP Target Studies in Populations With CKD
| Study | Description | BP Groups | Mean f/u, y | Kidney End Point |
|---|---|---|---|---|
| SPRINT subgroup with CKD73 (N = 2,646) | Aged ≥50 y, high CVD risk, UPCR < 1 g/g; eGFR > 20 mL/min/1.73 m2, no DM | SBP < 120 vs <140 mm Hg | 3.3 | HR, 0.90 (95% Cl, 0.44, 1.83) for composite of ≥50% decline in eGFR oi ESRD |
| REIN-295 (N = 338) | Aged 18–70 y, urine protein excretion 1 −3 g/d with CLcr < 45 mL/min or ≥3 g/d with CLcr < 70 mL/min | SBP/DBP < 130/80 mm Hg vs DBP < 90 mm Hg | 1.6 | HR, 1.00 (95% Cl, 0.61–1.64) for ESRD |
| AASK75 trial phase (N = 1,094) | 18–70 y, African Americans with clinically attributed hypertensive CKD, GFR 20–65 mL/min/1.73 m2, UPCR < 2.5 g/g, no DM | MAP ≤ 92 vs 102–107 mm Hg | 4.1 | HR, 1.06 (95% Cl, 0.89–1.27) for ESRD |
| AASK trial phase with UPCR > 0.22 g/g75 (N = 357) | 4.1 | HR, 0.76 (95% Cl, 0.55–1.04) for doubling of Scr or ESRD | ||
| AASK trial & cohort phases75 (N = 691) | 9.1 | HR, 0.95 (95% Cl, 0.78–1.15) for ESRD | ||
| AASK trial & cohort phases75 with UPCR > 0.22 g/g (N = 357) | 9.1 | HR, 0.76 (95% Cl, 0.58–0.99) for doubling of Scr or ESRD | ||
| MDRD Study trial phase88 (N = 840) | Aged 18–70 y with GFR 13–55 mL/min/1.73 m2 | MAP < 92 mm Hg if age ≤ 60 y & MAP < 98 mm Hg if age ≤ 61 y vs 107 mm Hg if age < 60 y & <113 mm Hg if age ≥ 61 y | 2.2 | HR, 0.78 (95% Cl, 0.66–0.93) for kidney failure |
| MDRD Study trial & cohort phases73 (N = 840) | 9.2 | HR, 0.68 (95% Cl, 0.57–0.82) for ESRD |
Abbreviations: AASK, African American Study of Kidney Disease and Hypertension; BP, blood pressure; CI, confidence interval; CKD, chronic kidney disease; CLcr creatinine clearance; CVD, cardiovascular disease; DBP, diastolic blood pressure; DM, diabetes mellitus; (e)GFR, (estimated) glomerular filtration rate; ESRD, end-stage renal disease; HR, hazard ratio; MAP, mean arterial pressure; MDRD, Modification of Diet in Renal Disease; REIN-2, Blood Pressure Control for Renoprotection in Patients With Non-Diabetic Chronic Renal Disease; SBP, systolic blood pressure; Scr, serum creatinine; SPRINT, Systolic Blood Pressure Intervention Trial; UPCR, urinary protein-creatinine ratio.