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. Author manuscript; available in PMC: 2019 Sep 12.
Published in final edited form as: Mol Pharm. 2019 May 13;16(6):2354–2363. doi: 10.1021/acs.molpharmaceut.8b01274

Figure 7.

Figure 7.

Opa60 proteoliposome uptake correlates with increased CEACAM expression on cell surface and is inhibited by treatment with staurosporine. (A) CEACAM1 cells were gated in to lowest 25%, middle 50%, and highest 25% expressing cells after staining with a pan-CEACAM antibody and the proteoliposome fluorescence for each sub-population was measured. A positive correlation was seen between CEACAM expression and Opa60 proteoliposome uptake. Error bars represent 95% C.I. (B) Treatment of CEACAM1 HeLa cells with the serine kinase inhibitor staurosporine inhibits Opa60 proteoliposome internalization into cells. Binding of proteoliposomes to the cell surface was unaffected by treatment. Error bars represent 95% C.I.