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. Author manuscript; available in PMC: 2020 Feb 20.
Published in final edited form as: Bioconjug Chem. 2018 Nov 15;30(2):443–453. doi: 10.1021/acs.bioconjchem.8b00723

Figure 4.

Figure 4.

(a) Retention and release profiles of iminothiolate (IT)-anchored siRNA versus dithiocarbamate (DTC)-anchored siRNA on GNRs labelled with HS-PEG-folate (340 pM; blue), versus controls without siRNA (red), in transfected SKOV-3 cells using CW laser irradiation (1.33 W/cm2, 15 min). eGFP knockdown experiments performed using 340 nM GNR–siRNA; efficiencies quantified by flow cytometry three days after laser treatment. (b) eGFP knockdown using DTC-anchored GNR–siRNA carriers (85 pM; blue) versus controls without siRNA (red), four days after pulsed laser treatment (0.6 W/cm2, 3 min). All measurements were performed in triplicate.