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Effect of ICV administration of 2 μg of MC-3/4R agonist (MTII) and 5 μg of CRF on renal sympathetic nerve activity (RSNA, mean of the fourth hour) in homozygous and heterozygous MC-4R knock-out mice as compared with their wild-type controls. Δ RSNA represents the percentage change in RSNA from baseline. Data represent mean ± SEM; n = 5–9 mice for each group. *p < 0.05 versus vehicle group; *p < 0.05 versus MC-4R (+/-) and MC-4R (-/-); #p < 0.05 versus MC-4R (-/-).
