Figure 10.

A, The adenosine A1 receptor antagonist DPCPX (500 nm) blocked forskolin-induced synaptic depression. Inset, Example traces of EPSCs. Holding potential was -80 mV. B, Summary plot of the change in EPSC size by forskolin application in the presence of CGP35348 (CGP; 500 μm), AM251 (AM; 4–5 μm), or DPCPX (500 nm). Data points labeled “NMDA” and “CGP” were measured from the late component of EPSCs at positive holding potentials, whereas the others were from EPSC sizes recorded at a holding potential of -80 mV.