Figure 4.
Effects of glutamate and Aβ25-35 under various conditions. Data represent percentage changes in the number of transported particles of control (the value before application). Glutamate (100 μm) (A, C, E) and Aβ25-35 (20 μm) (B, D, F) were applied after treatment with a combination of 20 μm MK-801, an NMDA receptor antagonist, and 100 μm CNQX, an AMPA receptor antagonist (A, B), in Ca2+-free solution (C, D), and after treatment with 5 μm latrunculin B, an actin depolymerizer (E, F). Each data point indicates the mean ± SD of the values obtained from five neurons. Error bars represent SD. *p < 0.05; **p < 0.005; ***p < 0.0005 compared with control (100%).