Skip to main content
. 2003 Oct 1;23(26):8949–8954. doi: 10.1523/JNEUROSCI.23-26-08949.2003

Figure 4.

Figure 4.

Ectopic expression of NF1GRD partially rescues the impaired cAMP response to PACAP in Nf1-/- astrocytes. Whereas reduced cAMP levels were observed in untransduced and vector transduced Nf1-/- (black bars) compared with Nf1+/+ (white bars) astrocytes, a partial restoration of this response was observed in astrocytes expressing the NF1GRD fragment. No effect on cAMP generation was observed in Nf1+/+ astrocytes expressing the NF1GRD fragment. Expression of KT3-tagged NF1GRD in Nf1-/- MSCV-NF1GRD-Pac treated astrocytes is shown in the inset. Each error bar represents mean ± SD. Asterisks denote statistically significant differences (*p = 0.001; **p = 0.005).