Cross-sectional study of Schaffer collateral-CA1 pathway synaptic transmission and plasticity in control (○,□) and PS2APP (•, ▪) mice. Experiments were performed using parallel cohorts of mice at 5, 9, 13, and 17 months of age. For each cohort, input-output parameters (left inset), paired-pulse plasticity (right inset), and LTP (*p < 0.05; ANOVA; 4-20 min after tetanus) were assayed (see Materials and Methods).