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. 2003 Aug 13;23(19):7358–7367. doi: 10.1523/JNEUROSCI.23-19-07358.2003

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Copyright © 2003 Society for Neuroscience 0270-6474/03/237358-10.00/0

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Figure 4. — Properties of IPSPs simulated as ideal current sources. A, Dendritic recordings of artificial (gray) and dIPSPs generated at the indicated sites, by IPSC-shaped ideal current sources or conductance changes, respectively, from a membrane potential of -60 mV. B, Pooled analysis of the site-dependent increase in local ( /•) and decrease in somatic (○) amplitude of IPSPs generated with an ideal current source (left) or conductance source (right). C, Comparison of the somatic kinetics after peak scaling of artificial IPSPs generated at dendritic (gray; 680 μm) and somatic sites under control and after I_H channel blockade with ZD 7288. The gray figures indicate the dendro-somatic attenuation of dendritic IPSPs. D, Relationship between somatic IPSP time course (half-width) of artificial IPSPs generated under control (○) and after I_H channel blockade ( ). Lines represent a linear regression (control) and a single exponential (ZD 7288). E, Pooled data showing the site dependence of the somatic rise time (10-90%) of artificial IPSPs under control (○) and following I_H channel blockade ( ). Lines represent a single exponential (control) and a linear regression (ZD 7288). Somatic points in B, D, and E represent mean ± SD.

Inline graphic — Properties of IPSPs simulated as ideal current sources. A, Dendritic recordings of artificial (gray) and dIPSPs generated at the indicated sites, by IPSC-shaped ideal current sources or conductance changes, respectively, from a membrane potential of -60 mV. B, Pooled analysis of the site-dependent increase in local ( /•) and decrease in somatic (○) amplitude of IPSPs generated with an ideal current source (left) or conductance source (right). C, Comparison of the somatic kinetics after peak scaling of artificial IPSPs generated at dendritic (gray; 680 μm) and somatic sites under control and after I_H channel blockade with ZD 7288. The gray figures indicate the dendro-somatic attenuation of dendritic IPSPs. D, Relationship between somatic IPSP time course (half-width) of artificial IPSPs generated under control (○) and after I_H channel blockade ( ). Lines represent a linear regression (control) and a single exponential (ZD 7288). E, Pooled data showing the site dependence of the somatic rise time (10-90%) of artificial IPSPs under control (○) and following I_H channel blockade ( ). Lines represent a single exponential (control) and a linear regression (ZD 7288). Somatic points in B, D, and E represent mean ± SD.