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. 2003 Aug 13;23(19):7317–7325. doi: 10.1523/JNEUROSCI.23-19-07317.2003

Figure 4.

Figure 4.

Ap-p38 kinase mediates short-term depression by releasing arachidonate. A, Ap-p38 kinase mediates short-term depression. The cells were treated with one 5 min pulse of FMRFa (1×F), which depressed the EPSP recorded at 5 min (-50.9 ± 10.6%; n = 8). Preincubation with the p38 kinase inhibitor SB 203580 (3 μm, 30 min) blocked the FMRFa-induced depression (1×F + SB; -12.7 ± 7.5%; n = 15; p < 0.05). The inhibitor alone (SB alone) had no short-term effect on the EPSP (-7.3 ± 5.6%; n = 7). Data were analyzed by ANOVA. Histograms show the percentage changes in the mean (±SE) of the EPSP amplitudes 5 min after the treatment. B, Ap-p38 kinase mediates the release of arachidonate. The FMRFa-induced release of arachidonate in pleural ganglia (Control, 1944.6 ± 305.7 pg, n = 7; FMRFa, 3658 ± 696.4 pg, n = 7) was blocked by 1 μm SB 203580 (FMRFa + SB, 1421 ± 249.3 pg, n = 6, p < 0.01). Data were analyzed by ANOVA.