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A, Schematic illustrations of chimeric G16 proteins with 44 C terminal amino acids of different Gα proteins and their ability to couple to T2Rs. +, Specifically responded to the ligand in a dose-dependent manner; -, did not exhibit any responses. B, Dose-dependent curves of the effects of ligands on the [Ca 2+]i in cells expressing G16/t2 or G16/i2 and the T2R receptor indicated.
