Figure 7.

Effects of 72 hr SD on hippocampus-mediated (A) and amygdala-mediated (B) memory. Y-axes show the mean (±SEM) amount of freezing as percentage of maximum (% max) possible for each group. A, Freezing in the context in which tone-shock pairings occurred 24 hr before test was significantly (^*p < 0.001) reduced in rats sleep deprived for 72 hr by the MP method (n = 9). Freezing in rats placed on the LP for 72 hr (n = 7) was intermediate between that of control (n = 9) and MP rats and not significantly different from either group. (Data were collapsed over the 6 min test period, during which no tones or shocks were delivered.) B, Freezing in a novel environment before (black bars) and after (gray bars) presentation of the cue (tone) that had been paired previously with shock was equivalent among all treatment groups. No shock was presented during this test.