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. 2003 Oct 22;23(29):9675–9686. doi: 10.1523/JNEUROSCI.23-29-09675.2003

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Copyright © 2003 Society for Neuroscience 0270-6474/03/239675-12.00/0

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Figure 7. — Fn14 colocalizes with Cdc42 and Rac1. Cos-7 cells were cotransfected with GFP-tagged Fn14 and myc -tagged wild-type Rho family GTPases. F-actin was visualized with rhodamine-phalloidin, and Rho family GTPases were visualized with 9E10 anti-myc antibody and Cy3-conjugated anti-mouse IgG antibody. A, Fn14 accumulates and colocalizes with F-actin at dorsal ruffles (arrowheads) and leading edge ruffles (arrows) but not at stress fibers (small arrows). B, C, Cdc42 and Rac1 distribution overlap extensively with that of Fn14 at dorsal ruffles (arrows) and leading edge ruffles (arrowheads). D, RhoA colocalizes with Fn14 at leading edge ruffles (arrowheads) but not at dorsal ruffles (arrows). Scale bar, 20 μm.