Table 1.
DRG mRNAs altered after sciatic axotomy
|
Gene |
Fold change |
Previous report of regulation by axotomy |
|---|---|---|
| Neuropeptide Y | 70.5 | Wakisaka et al., 1991 |
| Neurotensin | 25.2 | Zhang et al., 1996 |
| Complement component 1, q subcomponent | 16.9, 15.1, 5 | Mattsson et al., 1998 |
| ATF-3 | 16.8, 5.2 | Tsujino et al., 2000 |
| Histocompatibility 2, class II antigen A, α | 13.4 | None |
| Lysozyme P | 13.3 | None |
| LIM domain only protein 7 | 13.1 | None |
| Fibroblast growth factor inducible-14 (Fn14) | 9.6 | None |
| FLRT3 | 9.5 | None |
| A disintegrin and metalloprotease domain (ADAM) 8 | 9.1 | None |
| Retinoid-inducible serine carboxypeptidase precursor (Risc) | 8.7 | None |
| Acupuncture induced gene 1 (Aig1-pending), | 8.2 | None |
| SOX11 | 8, 6.8, 6.7, 5.8 | None |
| AI851735 | 7.9 | None |
| Fibroblast growth factor-regulated protein (Fgfrp) | 7.8 | None |
| Cyp 1-b-1 | 7.7 | None |
| Glucosaminyltransferase, I-branching enzyme | 7.4 | None |
| MHC class II H2-I-A-β gene (k haplotype) | 7.4 | None |
| Lysozyme M | 7.4 | None |
| AW125664 | 7.1 | None |
| MT3-MMP (membrane-type matrix metalloprotease) | 7 | None |
| ATP-binding cassette 1 | 7 | None |
| Myosin X | 7 | None |
| AA217038 | 6.6 | None |
| IGF-binding protein 3 | 6.3 | None |
| Galanin | 6.3 | Landry et al., 2000 |
| GADD45 protein | 6.2 | None |
| Protein tyrosine phosphatase, non-receptor type 1 (Ptpn1) | 5.9 | None |
| MPS1 | 5.7 | None |
| Ion channel homolog RIC | 5.7 | None |
| Lipocortin 1 = annexin-1 | 5.6 | None |
| AW123573 | 5.4 | None |
| AW125276 | 5.1 | None |
| Mitogen-responsive 96 kDa phosphoprotein p96 | 5 | None |
| AI834969 | -5.2 | None |
|
AW061035
|
-5.6
|
None
|
Those genes with expression level that is altered more than fivefold 1 week after sciatic nerve transection are listed. The genes studied here are in bold.