Figure 10.

MiRP2 broadens action potentials and lowers firing frequency in computer simulations. A, Membrane potentials in model neurons expressing 150 nS conductance Kv3.1, 150 nS conductance MiRP2/Kv3.1, or 100 nS MiRP2/Kv3.1 as indicated, during a simulated current injection of 0.05 nA for 250 msec. To the right of each train is an expanded picture of the final spike of the train. Failure to reach 0 mV is indicated by a line labeled “failure.” B, Membrane potentials in model neurons expressing 150 nS conductance Kv3.1, 150 nS conductance MiRP2/Kv3.1, or 100 nS MiRP2/Kv3.1 as indicated, during simulated current injections of 1.4 nA for 0.25 msec at frequencies or 100, 200, 300, and 350 Hz, as indicated. To the right of each train is an expanded picture of the final one to two spikes of the train. Failure to reach 0 mV is indicated by a line labeled “failure.” The asterisk indicates one example of undershoot in a model neuron expressing Kv3.1 alone.