Figure 2.

Cooling blocks the reconsolidation of a memory that has been reactivated. Operant training was administered (TR1-TR4) over the course of 2 d (n = 33). Then 7 d later 19 animals received a MR session (A), immediately followed by 1 hr of cooling (denoted by box), whereas the remaining animals (B; n = 14) received only the 1 hr of cooling. The group that received a MR session in conjunction with cooling did not demonstrate memory as tested 4 hr later. The remaining animals that did not receive a MR session but still received 1 hr of cooling still demonstrated memory during the test for savings; ^*p < 0.01 as compared with MR.