Figure 6.

Caspase inhibition reduces the resistance to CI conferred by ischemic preconditioning. Cultures were treated sham washes only (0 min PC), with 15 min of chemical ischemia (15 min PC), or with 15 min of chemical ischemia in the presence of 25 μm DEVD-CHO. After 24 hr the cultures were exposed to CI for durations of 0, 30, or 45 min. DEVD-CHO was added 2 hr before onset of PC and maintained until onset of CI. Neuronal death was assessed 24 hr after CI. ^**p < 0.01; representative of three independent experiments each with n = 3-4.