Table 1.

Summary of statistically significant effects of dopamine (10 μm) on pyramidal neuron physiology

	n (control/DA)	Control	10 μm DA	Change in DA (p < 0.05 for all)
VM (soma)	37/25	−80.4 ± 0.5 mV	−78.1 ± 0.7 mV	2.5 ± 0.4 mV
VM (dendrite)	40/36	−77.9 ± 0.6 mV	−74.8 ± 0.6 mV	3.0 ± 0.4 mV
RN (soma)	8	88 ± 15 MΩ	80 ± 6 MΩ	−7.7 ± 2.5%
RN (dendrite)	11	55 ± 6 MΩ	46 ± 6 MΩ	−16.9 ± 2.0%
Excitability (with depolarization)	21	5.2 ± 0.4 spikes	6.5 ± 0.8 spikes	20 ± 9%
Excitability (hyperpolarized)	12	5.8 ± 0.6 spikes	2.7 ± 0.9 spikes	−58 ± 13%

Excitability was measured either during dopamine-induced depolarization (with depolarization) or with the membrane potential adjusted to control levels with a somatic DC bias current (hyperpolarized). Excitability was measured as number of spikes in response to a given somatic current injection (∼300 pA, 1 sec). R_n, Input resistance; V_m, resting membrane potential.