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. 2003 Jul 16;23(15):6215–6222. doi: 10.1523/JNEUROSCI.23-15-06215.2003

Figure 5.

Figure 5.

PKC mediates the activation of NSCC induced by ORX-A. A, Mean whole-cell currents evoked by slow depolarizing (10 mV/sec) voltage ramps were recorded before and during exposure to ORX-A (10-8m) in the absence and presence of BIS II (1 μm). The difference currents induced by ORX-A (10-8m) in the absence (left panel) and presence of BIS II (1 μm) (right panel) are shown. B, This graph illustrates the mean ± SEM. ORX-A (10-8m) evoked current in the presence (filled squares; n = 6) and absence (open squares; n = 18) of BIS II (1 μm). The mean reversal potential and conductance of the ORX-A (10-8m)-sensitive current in the absence of BIS II are -42.4 ± 2.8 mV and 0.36 ± 0.02 nS (n = 18). Vm, Holding membrane potential. Error bars indicate SE.