Table 1.
Weight and metabolic variables in C57BL/6 and Apo E-deficient mice
|
Mice type |
Mice weight (g) |
Livers weight (g) |
Total cholesterol (mg/dl) |
VLDL+IDL+LDL (mg/dl) |
HDL (mg/dl) |
Triglycerides (mg/dl) |
Glycemia (mg/dl) |
|---|---|---|---|---|---|---|---|
| C57BL/6 wild-type mice | 33 ± 1 | 1.2 ± 0.1 | 96 ± 6 | 37 ± 4 | 58 ± 2 | 68 ± 7 | 173 ± 6 |
| Apo E-deficient mice | 33 ± 2 | 1.3 ± 0.1 | 545 ± 87 ** | 528 ± 84 ** | 16 ± 2 ** | 121 ± 11 * | 201 ± 5 * |
| Apo E-deficient and F
|
35 ± 3
|
2.9 ± 0.2 †
|
732 ± 74 **
|
728 ± 73 **#
|
3 ± 0.3 **##
|
111 ± 10 *
|
115 ± 5 *##
|
| C57BL/6 wild-type mice | 31 ± 1 | 1.2 ± 0.1 | 85 ± 9 | 32 ± 6 | 53 ± 3 | 61 ± 9 | 188 ± 29 |
| Wild-type mice and F
|
28 ± 1
|
2.2 ± 0.1 †
|
78 ± 10
|
30 ± 7
|
48 ± 2
|
53 ± 6
|
183 ± 37
|
†
p<0.0001
**
p<0.001
*
p<0.01
#
p<0.05 versus wild-type mice
##
p<0.001 versus untreated Apo E-deficient mice. F, Fenofibrate.