Figure 1.

Effect of MDMA and then clozapine on body temperature and cutaneous blood flow in one rabbit (A, B, intravenous injection of drugs) and in one rat (C, D, subcutaneous injection of drugs). The traces are continuously recorded Doppler ear pinna (rabbit) and tail (rat) signals and telemetrically measured continuously recorded intraperitoneal temperature signals. In both species, administration of MDMA causes intense cutaneous vasoconstriction and increase in body temperature. Both of these effects are reversed by subsequent administration of clozapine.