Figure 2.

Pattern of fMRI activity during the working-memory paradigm. fMRI activity for the combined-subjects (n = 31) random-effects analysis using a one-sample t test corrected for multiple comparisons at p < 0.05, contrasting the period of the task spent retrieving and/or manipulating information within working memory with the period during which maintenance (retention) of the same information was required. Significant activity was observed in the dorsolateral and ventrolateral prefrontal cortices (top and middle panels), the striatum (bottom panels), and posterior association cortices, bilaterally (middle left panel). The color scale represents the T statistic.