Table 1.
Effect of Homer on size and number of spines
|
Transfected with |
Width ± SEM of spine (μm) |
Length ± SEM of spine (μm) |
Number of spines per 10 μm of dendrite ± SEM |
|---|---|---|---|
| GFP alone | 0.75 ± 0.08 | 1.23 ± 0.09 | 4.2 ± 0.5 |
| GFP + Shank1B | 1.17 ± 0.10* | 1.39 ± 0.16* | 4.5 ± 0.9 |
| GFP + Shank1B + Homer1b | 1.33 ± 0.07*# | 1.72 ± 0.23*# | 3.9 ± 0.8 |
| GFP + Shank1B + Homer1a | 0.72 ± 0.07 | 1.09 ± 0.14& | 4.2 ± 0.5 |
| GFP + Shank1B + Homer1aW24A | 1.19 ± 0.09* | 1.37 ± 0.11* | 4.0 ± 0.4 |
| GFP + Homer1b | 0.68 ± 0.11 | 1.11 ± 0.14 | 4.6 ± 0.4 |
| GFP + Homer1a | 0.54 ± 0.09* | 0.95 ± 0.09* | 1.9 ± 0.4* |
| GFP + Homer1aW24A | 0.70 ± 0.13 | 1.21 ± 0.10 | 4.3 ± 0.5 |
| GFP + Shank1B1440-1849
|
0.56 ± 0.05*
|
1.01 ± 0.06*
|
1.4 ± 0.2*
|
*
Value statistically different (p<0.01) from neurons transfected with GFP.
&
Value statistically different (p<0.05) from neurons transfected with GFP.
#
Value statistically different (p<0.01) from neurons transfected with GFP and Shank1B.