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. 2003 Jul 16;23(15):6245–6254. doi: 10.1523/JNEUROSCI.23-15-06245.2003

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Copyright © 2003 Society for Neuroscience 0270-6474/03/236245-10.00/0

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Figure 6. — Effects of D2 receptor stimulation in D2L-/- and D2R-/-;D2L-/- mice. A, The graph shows the inhibitory effect of different doses of quinpirole (1–30 μm) on the amplitude of GABAergic IPSCs recorded from LA interneurons of WT, D2L-/-, and D2R-/-; D2L-/- mice. Although WT and D2L knock-outs respond to quinpirole in a similar manner, D2R-/-;D2L-/- mice show a significant reduction of sensitivity to quinpirole (p < 0.05 at 10 and 30 μm compared with control amplitudes, and p < 0.01 at 3, 10, and 30 μm quinpirole compared with WT and D2L-/- neurons). B, The graph shows the inhibitory effect of different doses of quinpirole (1–30 μm) on the amplitude of GABAergic IPSCs recorded from FS interneurons of WT, D2L-/-, and D2R-/-;D2L-/- mice. FS interneurons from WT and D2L knock-outs respond to quinpirole in a manner similar to that LA cells, whereas those from D2R-/-;D2L-/- animals show a significant reduction of sensitivity to quinpirole (p < 0.05 at 10 and 30 μm compared with control amplitudes, and p < 0.01 at 3, 10, and 30 μm quinpirole compared with WT and D2L-/- neurons recorded in the presence of this agonist).