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. 2003 Jul 16;23(15):6245–6254. doi: 10.1523/JNEUROSCI.23-15-06245.2003

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Copyright © 2003 Society for Neuroscience 0270-6474/03/236245-10.00/0

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Figure 8. — Effect of D2 receptor stimulation on sIPSC frequency and amplitude of WT and mutant LA interneurons. A, The histogram shows the average effect of 10 μm quinpirole on the frequency of GABAergic sIPSCs recorded from LA interneurons. Cells from WT, D2L-/-, and D2R-/-;D2L-/- mice are significantly affected by this drug (p < 0.01 for both WT and D2L-/- mice and p < 0.05 for D2R-/-;D2L-/- mice). The quinpirole-mediated synaptic inhibition observed in D2R-/-;D2L-/- neurons, however, was significantly less pronounced than the one observed in WT and D2L-/- mice (p < 0.05 compared with both WT and D2L-/- neurons). B, In the three genotypes, the reduction of sIPSC frequency is not paralleled by changes in their amplitude (p > 0.05), suggesting a presynaptic mechanism for this phenomenon.