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. 2003 Oct 15;23(28):9374–9384. doi: 10.1523/JNEUROSCI.23-28-09374.2003

Figure 11.

Figure 11.

The D2 antagonist S-(-)-raclopride attenuates the stimulatory but not the inhibitory effects of WIN55,212-2 on ACh efflux in the hippocampus. Raclopride administered subcutaneously at a dose of 1 mg/kg 15 min before WIN55,212-2 injection did not affect the stimulatory effects of WIN55,212-2 (0.5 mg/kg) (a) (F(1,7) = 0.22; NS; three-way ANOVA) but reversed the inhibitory effects of WIN55,212-2 (5 mg/kg) (b) (F(1,6) = 8.24; p < 0.05; three-way ANOVA) on ACh efflux in the hippocampus. Data (expressed as fold over baseline established before any treatment) represent mean ± SEM of n = 4-6 animals per group. *p < 0.05, **p < 0.01, and ***p < 0.001 for animals treated with S-(-)-raclopride before WIN55,212-2 versus animals treated with WIN55,212-2 only, at each time point.