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. 2003 Oct 15;23(28):9374–9384. doi: 10.1523/JNEUROSCI.23-28-09374.2003

Figure 5.

Figure 5.

WIN55,212-2 infused locally in the hippocampus inhibits ACh efflux in this region; reversal by SR141716A. a, Dose-dependent inhibition (F(36,72) = 2.24; p < 0.01; two-way ANOVA) of hippocampal ACh efflux after intrahippocampal infusion of WIN55,212-2 for 15 min (filled bar). Data (expressed as fold over baseline established before any treatment) represent mean ± SEM of n = 5-6 animals per group. Levels of statistical significance are pictured for the 0.1 mm dose of WIN55,212-2 only for clarity of the figure; *p < 0.05, *p < 0.01, and ***p < 0.001 for animals infused with WIN55,212-2 0.1 mm versus animals infused with vehicle at each time point. b, Intrahippocampal infusion of SR141716A (dashed bar) for 30 min (15 min before and throughout the 15 min infusion of WIN55,212-2) reversed the inhibitory effects of WIN55,212-2 (0.1 mm) on ACh efflux in the hippocampus (F(12,156) = 1.84; p < 0.05; three-way ANOVA). Data (expressed as fold over baseline established before any treatment) represent mean ± SEM of n = 4-6 animals per group. *p < 0.05, **p < 0.01, and ***p < 0.001 for animals infused with SR141716A and WIN55,212-2 versus animals infused with WIN55,212-2 only, at each time point.