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. 2003 Oct 15;23(28):9374–9384. doi: 10.1523/JNEUROSCI.23-28-09374.2003

Figure 8.

Figure 8.

PTX induced inactivation of Gi in the hippocampus blocks the inhibitory but not the stimulatory effects of WIN55,212-2 on ACh efflux in this region. Intrahippocampal infusion of PTX (100 ng; 24 hr before the microdialysis experiment) did not attenuate the stimulatory effects of WIN55,212-2 (0.5 mg/kg) (a) (F(11,44) = 1.22; NS; two-way ANOVA) but reversed the inhibitory effects of WIN55,212-2 (5 mg/kg) (b) (F(11,33) = 329; p < 0.001; two-way ANOVA) on ACh efflux in the hippocampus. Data (expressed as fold over baseline established before any treatment) represent mean ± SEM of n = 4-5 animals per group. *p < 0.05, **p<0.01, and ***p < 0.001 for animals pretreated with PTX and treated with WIN55,212-2 versus animals treated with WIN55,212-2 only, at each time point.