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. 2003 Oct 15;23(28):9374–9384. doi: 10.1523/JNEUROSCI.23-28-09374.2003

Figure 9.

Figure 9.

PTX induced inactivation of Gi in the septum blocks the stimulatory effects of WIN55,212-2 on ACh efflux in the hippocampus. Intraseptal infusion of PTX (100 ng; 24 hr before the microdialysis experiment) reversed the stimulatory effects of WIN55,212-2 (0.5 mg/kg) on ACh efflux in the hippocampus (F(11,44) = 2.29; p < 0.01; two-way ANOVA). Data (expressed as fold over baseline established before any treatment) represent mean ± SEM of n = 4-5 animals per group. *p < 0.05 and **p < 0.01 for animals pretreated with PTX and treated with WIN55,212-2 versus animals treated with WIN55,212-2 only, at each time point.