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. 2003 Oct 15;23(28):9418–9427. doi: 10.1523/JNEUROSCI.23-28-09418.2003

Figure 2.

Figure 2.

Gross brain and histopathological neuroprotection with sodium butyrate (SB) treatment. Photomicrographs of coronal serial step sections from the rostral neostriatum through the level of the anterior commissure in a wild-type littermate mouse (A1-A4), a sodium butyrate-treated (1.2 gm · kg-1 · d-1) R6/2 HD transgenic mouse (B1-B4), and a PBS-treated (C1-C4) R6/2 HD transgenic mouse at 90 d are shown. There was gross atrophy of the brain in the PBS-treated R6/2 mouse along with ventricular hypertrophy (C1-C4) compared with the wild-type littermate control mouse (A1-A4). In contrast, the sodium butyrate-treated R6/2 mouse brain (B1-B4) showed reduced gross brain atrophy and ventricular enlargement compared with the PBS-treated R6/2 mouse (C1-C4). Corresponding Nissl-stained tissue sections from the dorsomedial aspect of the neostriatum in a wild-type littermate control (A5), sodium butyrate-treated R6/2 mouse (B5), and PBS-treated R6/2 mouse (C5) are also shown. There was marked neuronal atrophy in the PBS-treated R6/2 mouse, with significantly less neuronal atrophy (p < 0.01) in the sodium butyrate-treated R6/2 mouse compared with this PBS-treated R6/2 mouse. The histogram shows means and SDs of somal areas of striatal neuronsquantitated in each group of mice (n = 10) (see Materials and Methods). Scale bars: A1-A4, B1-B4, C1-C4, 2 mm; A5, B5, C5, 100 μm.