Figure 5.
Striatal tissue immunohistochemistry of acetylated histone 4 in sodium butyrate-treated R6/2 mice. At 90 d of age, robust acetylated histone 4 immunohistochemistry was present in wild-type littermate control striatal tissue specimens (A), with hypoacetylation in the R6/2 mice (B). C, Sodium butyrate treatment (1.2 gm · kg-1 · d-1) increased acetylation of histone 4 in R6/2 mice. Scale bar: (in A) A-C, 100 μm.