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The composite NA effect is related to the coactivation of α1- and α2-receptors in the primary cell. A, NA effects on the membrane potential of a primary cell in control and in the presence of idazoxan to block the α2-receptor. B, NA effects on the membrane potential of another primary cell in control and in the presence of prazosin to block the α1-receptor. Note the hyperpolarization induced by NA in the presence of prazosin.
